The use of herbs is a time-honored approach to strengthening the body and treating disease. However, herbs can trigger side effects and can interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider.
Anyone with a personal or family history of hormone-related cancer (such as breast cancer, ovarian cancer, and uterine cancer) should check with their doctor before using any form of natural hormone replacement, including wild yam. Although it does not seem to act like a hormone in the body, there is a slight risk that wild yam could produce similar effects to estrogen.
Pregnant women and nursing mothers should avoid wild yam.
People who have protein S deficiency should not take wild yam without talking to their doctor. Some doctors think wild yam may possibly increase the risk of forming clots, because of its estrogen-like effects.